Edit |   |
---|---|
Antigenic Specificity | DDR1 |
Clone | [1464CT339.1.54] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b,k |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This DDR1 antibody is generated from a mouse immunized with a recombinant protein. Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for |
Immunogen | n/a |
Other Names | [Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2; Mammary carcinoma kinase 10; MCK-10; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; TRK] |
Gene, Accession # | [DDR1], Gene ID: 780, NCBI: NP_001189450.1, UniProt: Q08345 |
Catalog # | MBS9200339 |
Price | $165, $370 |
Order / More Info | DDR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | di Marco E.,et al.J. Biol. Chem. 268:24290-24295(1993). Johnson J.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993). Laval S.,et al.Cell Growth Differ. 5:1173-1183(1994). Perez J.L.,et al.Oncogene 9:211-219(1994). Sakuma S.,et al.FEBS Lett. 398:165-169(1996). |