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Antigenic Specificity | RICTOR |
Clone | [7B3] |
Host Species | Mouse |
Reactive Species | human, monkey, mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals. mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GbetaL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GbetaL, Sin1 and rictor. The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro. This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes. This complex has also been shown to phosphorylate the |
Immunogen | Immunogen: Purified recombinant fragment of human RICTOR expressed in E Coli. |
Other Names | [PIA; mAVO3; KIAA1999; MGC39830; DKFZp686B11164; RICTOR], [PIA; mAVO3; KIAA1999; MGC39830; DKFZp686B11164; RICTOR] |
Gene, Accession # | [RICTOR], Gene ID: 253260, NCBI: NP_001272369.1, UniProt: Q6R327 |
Catalog # | MBS476058 |
Price | $335 |
Order / More Info | RICTOR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |