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Antigenic Specificity | NMDA RECEPTOR NR2B (pTyr1252) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | bovine (expected from sequence), chicken (expected from sequence), dog (expected from sequence), human (expected from sequence), mouse (expected from sequence), zebrafish (expected from sequence) |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB)* |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This item specifically recognises the 180kDa NR2B subunit of the NMDA (N-methyl-D-aspartate) receptor when phosphorylated at Tyrosine 1252. Receptors for NMDA belong to a group of ionotropic glutamate receptors which play a key role in the mediation of glutamate neurotransmission within the mammalian central nervous system (CNS), including involvement in memory and learning processes. Several antagonists and agonists of NMDA receptors (NMDAR) have been identified, including the glutamate analogue Homoquinolinic acid, which displays a higher affinity for NR2B-containing NMDAR. Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage-dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS |
Immunogen | Immunogen: Phosphopeptide corresponding to smino acid residues surrounding the phosphorylated tyrosine 1252 of the NR2B subunit of rat NMDA receptor. Buffer Solution: 10 mM Hepes pH7.5 Antiserum Preparation: Antisera to rat NMDAR NR2B subunit pTyr1252 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Rat |
Other Names | [glutamate receptor ionotropic, NMDA 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor ionotropic, NMDA 2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B], [Grin2b; Grin2b; GluN2B; GluN2B; NMDAR2B; NR2B] |
Gene, Accession # | [NMDA], Gene ID: 24410, NCBI: NP_036706.1, UniProt: Q00960 |
Catalog # | MBS221522 |
Price | $550 |
Order / More Info | NMDA RECEPTOR NR2B (pTyr1252) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |