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Antigenic Specificity | Blimp-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells. Together with X-box-binding protein 1 (XBP1), Blimp-1 is induced upon terminal differentiation of plasma cells. The transcriptional repressor activity of Blimp-1 has also been found to regulate T cell homeostasis and function, possibly by suppressing the expression of the cytokines IL-2 and interferon-gamma during T cell development. More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2. |
Other Names | [Presenilin enhancer protein 2, Gamma-secretase subunit PEN-2] |
Gene, Accession # | [Blimp-1], Gene ID: 639, NCBI: NP_001189 |
Catalog # | MBS9402638 |
Price | $320 |
Order / More Info | Blimp-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |