MAPT Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-MAPT antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | MAPT |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tau is a heterogeneous microtubuleassociated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different aminoterminal inserts and different numbers of tandem repeats near the carboxyterminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK3 and CDK5 (12). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other n |
| Immunogen | Immunogen: A synthetic -peptide of human MAPT |
| Other Names | [MAPT; Tau; Tau; MAPT; DDPAC; FLJ31424; FTDP17; MAPTL; MGC138549; MSTD; MTBT1; MTBT2; PPND; TAU], [MAPT; MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; MAPTL; MTBT1; TAU; PHF-tau] |
| Gene, Accession # | Gene ID: 4137, NCBI: NP_001116538.2, UniProt: P10636 |
| Catalog # | MBS125717 |
| Price | $200, $275, $430 |
| Order / More Info | MAPT Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Johnson, G.V. and Stoothoff, W.H. (2004) J. Cell Sci. 117, 5721-5729. 2. Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476. 3. Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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