ERp57 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | ERp57 |
| Clone | [4F9] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~57 kDa protein. ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttrans |
| Immunogen | Immunogen: Human recombinant ERp57 (Grp58) protein corresponding to amino acids 25- 505 (his-tagged). Immunogen Species: Human. Cellular Localization: Endoplasmic Reticulum; Endoplasmic Reticulum Lumen; Melanosome. Conjugate: Unconjugated. Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Other Names | [Mouse Human ERp57 IgG2b; ERp57; ERp60; ERp61; Grp57; Grp58; P58; PDIA3; PI PLC; 58 kDa glucose regulated protein; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER 60; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER p57; ER protein 57; ER protein 60; ERp 57; ERp57; Glucose Regulated Protein 58 Kd; GRP 57; GRP 58; GRP57; HsT17083; p58; PDIA 3; PDIA3; PDIA3_HUMAN; Phospholipase C alpha; PI PLC; Protein disulfide isomerase A3; Protein disulfide isomerase family A member 3; Protein disulfide-isomerase A3], [PDIA3; PDIA3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n; ERP57; ERP60; GRP58; p58; ER protein 57; ERp57; ER protein 60; ERp60] |
| Gene, Accession # | [ERp57], Gene ID: 2923, NCBI: NP_005304.3, UniProt: P30101 |
| Catalog # | MBS808430 |
| Price | $390 |
| Order / More Info | ERp57 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Herbert D.N. and Molinari M. (2007) Physiol Rev. 87: 1377-1408. 2. Williams D.B. (2005) J Cell Sci. 119: 615-623 3. Maattanen P., et al. (2006) Biochem Cell Biol. 84: 881-889. 4. Oliver J.D., et al. (1999) Mol Bio Cell. 10: 2573-2582. 5. Oliver J.D., et al. (1997) Science 275: 86-88. 6. Solda T., et al. (2006) J Biol Chem 281: 6219-6226. 7. Kimura T., et al. (2005) Biochem Biophys Research Communications. 331 (1): 224-230. 8. Chen, G., et al. (2002) Clin Cancer Res 8(7): 2298-2305. 9. Tan, P., et al. F. (2002) J Immunol 168(4): 1950-1960. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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