NEDD4L (Center), 576-604 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | NEDD4L (Center), 576-604 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This NEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK. |
| Immunogen | n/a |
| Other Names | [E3 ubiquitin-protein ligase NEDD4-like; 632-; NEDD42; Nedd4-2; NEDD4L; KIAA0439; NEDL3] |
| Gene, Accession # | [NEDD4L], Gene ID: 23327, NCBI: NP_001138436.1, UniProt: Q96PU5 |
| Catalog # | MBS9207975 |
| Price | $165, $370 |
| Order / More Info | NEDD4L (Center), 576-604 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zhou, R., et al. J. Biol. Chem. 285(40):30523-30530(2010) Raikwar, N.S., et al. Am. J. Physiol. Renal Physiol. 299 (2), F436-F444 (2010) : Hallows, K.R., et al. J. Biol. Chem. 285(28):21671-21678(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Jin, H.S., et al. Kidney Blood Press. Res. 33(1):15-23(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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