SATB1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificitySATB1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
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DescriptionSpecial AT-rich binding protein 1 (SATB1) functions as both a global chromatin organizer and a gene-specific transcription factor (1). SATB1 cooperates with promyelocytic leukemia protein (PML) to regulate global chromatin architecture by organizing chromatin into distinct loops via periodic anchoring of matrix attachment regions (MARs) in DNA to the nuclear matrix (1-3). In addition, SATB1 recruits multiple chromatin-remodeling proteins that contribute to specific gene activation and repression, including the chromatin remodeling enzymes ACF and ISWI, the histone deacetylase HDAC1, and the histone acetyltransferases PCAF and p300/CBP (4-6). Phosphorylation of SATB1 on Ser185 by protein kinase C regulates its interaction with HDAC1 and PCAF
ImmunogenImmunogen: A synthetic peptide of human SATB1
Other Names[SATB1; SATB1; SATB1; DNAbinding protein SATB1;], [SATB1; SATB1]
Gene, Accession #Gene ID: 6304, NCBI: NP_001124482.1, UniProt: Q01826
Catalog #MBS128128
Price$275, $430, $655
Order / More InfoSATB1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Galande, S. et al. (2007) Curr Opin Genet Dev 17, 408-14. 2. Cai, S. et al. (2006) Nat Genet 38, 1278-88. 3. Kumar, P.P. et al. (2007) Nat Cell Biol 9, 45-56. 4. Yasui, D. et al. (2002) Nature 419, 641-5. 5. Kumar, P.P. et al. (2005) Mol Cell Biol 25, 1620-33. 6. Pavan Kumar, P. et al. (2006) Mol Cell 22, 231-43. 7. Han, H.J. et al. (2008) Nature 452, 187-93.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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