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Antigenic Specificity | NEFA/NUCB2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~54 kDa of NEFAS protein. It reacts with rat and mouse. The other species are not tested. NEFA, a 420 amino acid protein (also known as NUCB2, nucleobindin 2, p54), is a DNA-binding protein localizing in the Golgi Apparatus. This protein has been implicated in various functions, including Ca2+ homeostasis, hypothalamic regulation of feeding and TNF-receptor-1 (TNFR1) shedding. NUCB2 has been shown to interact with both necdin and ARTS-1, both through the EF-hand motif. The NUCB2-ARTS-1 complex is required for the proteolytic cleavage and release of TNFR1 to the extracellular compartment. NUCB2 has been identified as a novel satiety molecule in the hypothalamous associated with melanocortin signaling in the central n |
Immunogen | n/a |
Other Names | [Nucleobindin 2], [NUCB2; NUCB2; NEFA; HEL-S-109; NEFA] |
Gene, Accession # | [NEFA/NUCB2], Gene ID: 4925, NCBI: NP_001339601.1 |
Catalog # | MBS460342 |
Price | $275 |
Order / More Info | NEFA/NUCB2 Antibody from MYBIOSOURCE INC. |
Product Specific References | Taniguchi, N et al, The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J. Biol. Chem. 275 (41), 31674-31681 (2000). |