NEFA/NUCB2 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityNEFA/NUCB2
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat
Isotypen/a
Formatepitope affinity purified
Size0.1 mg
Concentrationn/a
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
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DescriptionThis antibody recognizes ~54 kDa of NEFAS protein. It reacts with rat and mouse. The other species are not tested. NEFA, a 420 amino acid protein (also known as NUCB2, nucleobindin 2, p54), is a DNA-binding protein localizing in the Golgi Apparatus. This protein has been implicated in various functions, including Ca2+ homeostasis, hypothalamic regulation of feeding and TNF-receptor-1 (TNFR1) shedding. NUCB2 has been shown to interact with both necdin and ARTS-1, both through the EF-hand motif. The NUCB2-ARTS-1 complex is required for the proteolytic cleavage and release of TNFR1 to the extracellular compartment. NUCB2 has been identified as a novel satiety molecule in the hypothalamous associated with melanocortin signaling in the central n
Immunogenn/a
Other Names[Nucleobindin 2], [NUCB2; NUCB2; NEFA; HEL-S-109; NEFA]
Gene, Accession #[NEFA/NUCB2], Gene ID: 4925, NCBI: NP_001339601.1
Catalog #MBS460342
Price$275
Order / More InfoNEFA/NUCB2 Antibody from MYBIOSOURCE INC.
Product Specific ReferencesTaniguchi, N et al, The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J. Biol. Chem. 275 (41), 31674-31681 (2000).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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