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Antigenic Specificity | FZD10 (N-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This FZD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-212 amino acids from the N-terminal region of human FZD10. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to in |
Immunogen | n/a |
Other Names | [Frizzled-10; Fz-10; hFz10; FzE7; CD350; FZD10] |
Gene, Accession # | [FZD10], Gene ID: 11211, NCBI: NP_009128.1, UniProt: Q9ULW2 |
Catalog # | MBS9201169 |
Price | $165, $370 |
Order / More Info | FZD10 (N-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Koike J.,et al.Biochem. Biophys. Res. Commun. 262:39-43(1999). Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998). Kwon H.S.,et al.Mol. Cell. Biol. 29:2139-2154(2009). |