Edit |   |
---|---|
Antigenic Specificity | ATM |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, a |
Immunogen | Immunogen: A synthesized peptide derived from human ATM |
Other Names | [Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated; ATM] |
Gene, Accession # | [ATM], Gene ID: 472, NCBI: NP_000042.3, UniProt: Q13315 |
Catalog # | MBS7114926 |
Price | $185, $265 |
Order / More Info | ATM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |