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Antigenic Specificity | Caspase-9 (Active) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47 kDa) and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37 kDa/17 kDa) and a small subunit (10 kDa). Cleaved caspase-9 further processes other caspases including caspase-3 and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells. |
Immunogen | Immunogen: Synthetic peptide mapping to the N-terminus adjacent to Asp330 of human caspase-9 |
Other Names | [CASP-9; EC 3.4.22.62; ICE-like apoptotic protease 6,ICE-LAP6,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3; Apaf-3], [Casp9; Casp9; Mch6; APAF-3; CASP-9; AI115399; AW493809; ICE-LAP6; Caspase-9; Mch6; CASP-9; APAF-3; ICE-LAP6] |
Gene, Accession # | Gene ID: 12371, NCBI: BAA86895 |
Catalog # | MBS840456 |
Price | $460 |
Order / More Info | Caspase-9 (Active) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |