Human Rapamycin-insensitive companion of mTOR Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Rapamycin-insensitive companion of mTOR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'S |
| Immunogen | Immunogen: Recombinant human Rapamycin-insensitive companion of mTOR protein(1-245aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50678 / sc-130865 / sc-99004 |
| Other Names | [AVO3 homolog; hAVO3; RICTOR], [RICTOR; RICTOR; PIA; AVO3; hAVO3; hAVO3] |
| Gene, Accession # | [RICTOR], Gene ID: 253260, NCBI: NP_001272368.1, UniProt: Q6R327 |
| Catalog # | MBS1497727 |
| Price | $120, $160 |
| Order / More Info | Human Rapamycin-insensitive companion of mTOR Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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