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Antigenic Specificity | RNF40 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RNF40 (NP 055586.1). |
Other Names | [BRE1B; RBP95; STARING] |
Gene, Accession # | [RNF40], NCBI: O75150.4, UniProt: O75150 |
Catalog # | MBS8546113 |
Price | $280 |
Order / More Info | RNF40 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |