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Antigenic Specificity | Mouse CD40 |
Clone | [2/23] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a |
Format | biotin conjugate |
Size | 0.1 mg, 0.3 mg |
Concentration | Antibody concentration: 0.1 mg/ml |
Applications | Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD40 (gp39 receptor) (Mouse CD40). anti-mouse monoclonal antibody reacts with CD40 which is expressed on B-lymphocytes and on a subset of both CD4+ and CD8+ T cells in the adult (but not neonatal) spleen1. The level of CD40 on B cells is enhanced following activation buy LPS1. The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal center formation, and generating B cell memory2. Stimulating cells with immobilized 3/23 mAb increases expression of CD86 (B7.2) on B cells1,3. Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3. Costimulation with 3/23 mAb and IL-4 rescues |
Immunogen | n/a |
Other Names | [CD40, Biotin (Clone 3/23) (rat IgG2a); Biotin Mouse CD40], [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: NP_690593.1, UniProt: P25942 |
Catalog # | MBS520120 |
Price | $200, $370 |
Order / More Info | Mouse CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |