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Antigenic Specificity | Human Dkk-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg, 0.2 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/betacatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/betacatenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posteri |
Immunogen | Antibody Generation: Purified from sera of rabbits immunized with highly pure recombinant human DKK1 produced in E Coli. Antigen: Recombinant Human Dkk-1 |
Other Names | [Dickkopf-related protein-1; Dickkopf-1; SK], [DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1] |
Gene, Accession # | [Dkk-1], Gene ID: 22943, NCBI: NP_036374.1, UniProt: O94907 |
Catalog # | MBS692265 |
Price | $280, $390 |
Order / More Info | Human Dkk-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |