lc3A/B Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | lc3A/B |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: lc3A/B detects endogenous levels of total lc3A/B. Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.Subunit Structure: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B protein |
| Immunogen | Immunogen: A synthesized peptide derived from human lc3A/B Subcellular Location: Cytoplasm > Cytoskeleton. Endomembrane System. Cytoplasmic Vesicle > Autophagosome Membrane. LC3-II binds to the autophagic membranes. Tissue Specificity: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Sheep, Dog, Xenopus Similarity: Pig (100%), Zebrafish (93%), Bovine (100%), Sheep |
| Other Names | [ATG8F; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; LC3B; LC3II; MAP1 light chain 3 like protein 2; MAP1 light chain 3-like protein 2; MAP1A/1BLC3; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1ALC3; MAP1LC3B a; Map1lc3b; Microtubule associated protein 1 light chain 3 beta; Microtubule-associated protein 1 light chain 3 beta; Microtubule-associated proteins 1A/1B light chain 3B; MLP3B_HUMAN] |
| Gene, Accession # | [lc3A/B], Gene ID: 81631, NCBI: NP_073729.1, UniProt: Q9GZQ8 |
| Catalog # | MBS9601573 |
| Price | $240, $280 |
| Order / More Info | lc3A/B Antibody from MYBIOSOURCE INC. |
| Product Specific References | Tang Z, Cui K, Luan Y, Ruan Y, Wang T, Yang J, Wang S, Liu J, Wang D; Journal: Andrology. Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats. Shao L, Yang W, Xu R, Zhu S, Huang Y, Li H, Wu X, Yue M, Xiong X, Chen X, Kuang B, Fan G, Zhu Q, Zeng H; Journal: Stem Cell Res Ther. Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells. Wu CZ, Zheng JJ, Bai YH, Xia P, Zhang HC, Guo Y; Journal: Onco Targets Ther. HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma. Feng X, Lu J, He Z, Wang Y, Qi F, Pi R, Zhang G; Journal: Front Cell Infect Microbiol. Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells. shuaishuai Zhang, Junqin Li, Huijie Jiang, Yi Gao, Pengzhen Cheng, Tianqing Cao, Donglin Li, Jimeng Wang, Yue Song, Bing Liu, Hao Wu, Chun-Mei Wang, Liu Yang, and Guoxian Pei; Journal: STEM CELLS INT. |
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MYBIOSOURCE INC.
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