CD80 (B7-1) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD80 (B7-1) |
| Clone | [C80/1608] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | ELISA (EIA), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated |
| Immunogen | Immunogen: Recombinant human full-length CD80 protein Cellular Localization: Cell Surface |
| Other Names | [Activation B7-1 antigen; B lymphocyte activation antigen B7; B7; B7-1; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80; Costimulatory factor CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80] |
| Gene, Accession # | [CD80], Gene ID: 941, NCBI: NP_005182.1, UniProt: P33681 |
| Catalog # | MBS4380335 |
| Price | $190, $340, $340 |
| Order / More Info | CD80 (B7-1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Peach, R.J., et al. 1995. Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J. Biol. Chem. 270: 21181-21187. Fargeas, C.A., et al. 1995. Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J. Exp. Med. 182: 667-675. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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