CDK5R1 (p35) (C-term), 272-301 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CDK5R1 (p35) (C-term), 272-301 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This CDK5R1(p35) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1(p35). p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accum |
| Immunogen | n/a |
| Other Names | [Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1; p35; p35; Cyclin-dependent kinase 5 activator 1; p25; p25; Tau protein kinase II 23 kDa subunit; p23; CDK5R1; CDK5R; NCK5A] |
| Gene, Accession # | [CDK5R1], Gene ID: 8851, NCBI: NP_003876.1, UniProt: Q15078 |
| Catalog # | MBS9207600 |
| Price | $165, $370 |
| Order / More Info | CDK5R1 (p35) (C-term), 272-301 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Lin,S., FEBS Lett. 582 (8), 1197-1202 (2008) Sen,A., Neuroreport 18 (5), 511-516 (2007) Mitsios,N., Brain Pathol. 17 (1), 11-23 (2007) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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