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Antigenic Specificity | KSHV ORF45 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was |
Immunogen | Immunogen: Purified recombinant fragment of KSHV ORF45 expressed in E. Coli |
Other Names | [ORF45], [ORF45] |
Gene, Accession # | [KSHV ORF45], Gene ID: 4961474, NCBI: YP_001129397.1 |
Catalog # | MBS850694 |
Price | $280 |
Order / More Info | KSHV ORF45 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |