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Antigenic Specificity | ARH (LDLRAP1) (N-term), 11-42 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ARH (LDLRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-42 amino acids from the N-terminal region of human ARH (LDLRAP1). LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by sta |
Immunogen | n/a |
Other Names | [Low density lipoprotein receptor adapter protein 1; Autosomal recessive hypercholesterolemia protein; LDLRAP1; ARH] |
Gene, Accession # | [LDLRAP1], Gene ID: 26119, NCBI: NP_056442.2, UniProt: Q5SW96 |
Catalog # | MBS9206647 |
Price | $165, $370 |
Order / More Info | ARH (LDLRAP1) (N-term), 11-42 Antibody from MYBIOSOURCE INC. |
Product Specific References | Maurer,M.E., J. Cell. Sci. 119 (PT 20), 4235-4246 (2006) Keyel,P.A., Mol. Biol. Cell 17 (10), 4300-4317 (2006) |