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Antigenic Specificity | Phospho-HER4-Y1284 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The HER/ErbB receptor tyrosine kinase family has been implicated in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported suggesting that ErbB4 expression is involved in both normal tissue develo |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y1284 of human HER4 |
Other Names | [Phospho-ERBB4-Y1284: ERBB4; HER4; p180erbB4; MGC138404], [ERBB4; ERBB4; HER4; ALS19; p180erbB4; HER4; 4ICD; E4ICD] |
Gene, Accession # | [ErbB4], Gene ID: 2066, NCBI: Q15303.1, UniProt: Q15303 |
Catalog # | MBS125808 |
Price | $235, $350, $525 |
Order / More Info | Phospho-HER4-Y1284 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |