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Antigenic Specificity | DR6 (NT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-DR6 (NT) [Rabbit antibody to peptide corresponding to aa 42-56 of human DR6 precursor.]. This antibody recognizes human DR6 (68 kD). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domaincontaining receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain-containing receptor in the TNF receptor family was recently described and designated DR6. Like TNF-R1, DR6 interacts with death domain-containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF- kappa B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 is under investigation |
Immunogen | Antigen: Peptide corresponding to aa 42- 56 of human DR6 precursor. |
Other Names | [DR6 (NT); DR6 (NT)], [DR6L] |
Gene, Accession # | UniProt: Q89584 |
Catalog # | MBS194075 |
Price | $415 |
Order / More Info | DR6 (NT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |