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Antigenic Specificity | HSPA5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total HSPA5 antibody. Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including HSPA5. HSPA5 was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, HSPA5 synthesis is increased. Subsequently, HSPA5 binds to misfolded proteins to prevent them from forming aggregates and assists in pro |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human HSPA5. |
Other Names | [HSPA5; BIP; FLJ26106; GRP78; MIF2] |
Gene, Accession # | [HSPA5], Gene ID: 3309, NCBI: NP_005338.1, UniProt: P11021 |
Catalog # | MBS9412690 |
Price | $255 |
Order / More Info | HSPA5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |