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Antigenic Specificity | Human SATB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | DyLight 488 conjugate |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: No cross reactivity with other proteins. SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene. SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of I |
Immunogen | Immunogen: E Coli-derived human SATB1 recombinant protein (Position: D638-D763). |
Other Names | [Rabbit IgG Human SATB1 DyLight 488 Conjugated, Flow Validated; DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1; SATB1; SATB homeobox 1] |
Gene, Accession # | [SATB1], Gene ID: 6304, NCBI: NP_001124482.1, UniProt: Q01826 |
Catalog # | MBS1751330 |
Price | $330 |
Order / More Info | Human SATB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Galande S, Purbey PK, Notani D, Kumar PP (Oct 2007). The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1. Current Opinion in Genetics & Development. 17 (5): 408-14. 2. Pavan Kumar P, Purbey PK, Sinha CK, Notani D, Limaye A, Jayani RS, Galande S (Apr 2006). Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Molecular Cell. 22 (2): 231-43. |