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Antigenic Specificity | PUM1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, pho |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human pum1 (NP 055491.1). |
Other Names | [PUMH; HSPUM; PUMH1; PUML1; SCA47] |
Gene, Accession # | [PUM1], Gene ID: 9698, NCBI: NP_001018494.1, UniProt: Q14671 |
Catalog # | MBS8548986 |
Price | $280 |
Order / More Info | PUM1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |