Edit |   |
---|---|
Antigenic Specificity | Mouse CD132 |
Clone | [3E12] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common gamma chain (gammac) or IL-2 receptor gamma subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID). |
Immunogen | n/a |
Other Names | [Mouse CD132; Cytokine receptor common subunit gamma; Il2rg; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD132] |
Gene, Accession # | [CD132], Gene ID: 16186, NCBI: NP_038591.1, UniProt: P34902 |
Catalog # | MBS2553775 |
Price | $85, $100 |
Order / More Info | Mouse CD132 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Itano M, et al. 1996. Tohoku J. Exp. Med. 178:389. 2. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication. 3. Nakarai T, et al. 1994. J. Exp. Med. 180:241. 4. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724. 5. Habib T, et al. 2002. Biochemistry. 41:8725. 6. Matthews DJ, et al. 1995. Blood 85:38. |