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Antigenic Specificity | Phospho-AKT2 (S474) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Phospho-AKT2-S474 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S474 of human AKT2. AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins. |
Immunogen | n/a |
Other Names | [RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta; AKT2] |
Gene, Accession # | [AKT2], Gene ID: 208, NCBI: NP_001617.1, UniProt: P31751 |
Catalog # | MBS9206389 |
Price | $165, $370 |
Order / More Info | Phospho-AKT2 (S474) Antibody from MYBIOSOURCE INC. |
Product Specific References | George, S., et al., Science 304(5675):1325-1328 (2004). Xu, X., et al., Oncol. Rep. 11(1):25-32 (2004). Shim, D., et al., Arch. Biochem. Biophys. 425(2):214-220 (2004). Li, X., et al., Gastroenterology 126(1):122-135 (2004). Vojtek, A.B., et al., Mol. Cell. Biol. 23(13):4417-4427 (2003). |