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Antigenic Specificity | BRE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: BRE antibody detects endogenous levels of total BRE. Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks. Tissue Specificity: Expressed in all cell lines examined. Highly expressed in placenta. Predicted Cross Reactivity: Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Zebrafish (91%), Bovine (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%) |
Other Names | [6030405P19Rik; AI429776; B830038C02Rik; Brain and reproductive organ expressed (TNFRSF1A modulator); brain and reproductive organ expressed protein; Brain and reproductive organ-expressed protein; BRCA1 A complex subunit BRE; BRCA1-A complex subunit BRE; BRCA1/BRCA2 containing complex subunit 4; BRCA1/BRCA2 containing complex subunit 45; BRCA1/BRCA2-containing complex subunit 45; BRCC4; BRCC45; bre; BRE_HUMAN] |
Gene, Accession # | [BRE], Gene ID: 9577, NCBI: NP_001248769.1, UniProt: Q9NXR7 |
Catalog # | MBS9606140 |
Price | $240, $280 |
Order / More Info | BRE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |