Edit |   |
---|---|
Antigenic Specificity | Caspase-4 (NT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggeste |
Immunogen | Immunogen: Rabbit polyclonal Caspase-4 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4. |
Other Names | [ICH-2; ICE(rel)-II; Mih1 (IN)], [CASP4; CASP4; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; ICH2; CASP-4] |
Gene, Accession # | Gene ID: 837, NCBI: AAA86890, UniProt: P49662 |
Catalog # | MBS395993 |
Price | $510 |
Order / More Info | Caspase-4 (NT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |