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Antigenic Specificity | EHMT2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Histone methyltransferase that specifically mono-and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 877-1176 of human EHMT2 (NP 079532.5). |
Other Names | [G9A; BAT8; GAT8; NG36; KMT1C; C6orf30] |
Gene, Accession # | [EHMT2], Gene ID: 10919, NCBI: Q96KQ7.3, UniProt: Q96KQ7 |
Catalog # | MBS8544343 |
Price | $280 |
Order / More Info | EHMT2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |