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Antigenic Specificity | notch1a |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | zebrafish |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER a |
Immunogen | Immunogen: Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) |
Other Names | [Neurogenic locus notch homolog protein 1; Notch 1; Notch 1 extracellular truncation; NEXT; Notch 1 intracellular domain; NICD; notch1a; notch] |
Gene, Accession # | [notch1a], Gene ID: 30718, NCBI: NP_571516.1, UniProt: P46530 |
Catalog # | MBS7104358 |
Price | $160, $235 |
Order / More Info | notch1a Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |