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Antigenic Specificity | TPH2 (Phospho-Ser19) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19. This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.Walther D.J., Science 299:76-76(2003).Scherer S.E., Nature 440:346-351(2006). |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2. |
Other Names | [ADHD7; NTPH; TPH2] |
Gene, Accession # | [TPH2], Gene ID: 121278, NCBI: NP_775489.2, UniProt: Q8IWU9 |
Catalog # | MBS9409804 |
Price | $200, $255 |
Order / More Info | TPH2 (Phospho-Ser19) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |