POLD1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | POLD1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: POLD1 antibody detects endogenous levels of total POLD1. Function: As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'-to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nucleus. Tissue Specificity: Widely expressed, with high levels of expression in heart and lung. Predicted Cross Reactivity: Zebrafish, Bovine, Horse, Xenopus Similarity: Zebrafish (91%), Bovine (100%), Horse (100%), Xenopus (91%) |
| Other Names | [Polymerase (DNA directed) delta 1 catalytic subunit; CDC2; CDC2 homolog; CRCS10; DNA directed DNA polymerase delta 1; DNA directed polymerase delta 1; DNA pol delta 1; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125; DPOD1_HUMAN; MDPL; POLD; POLD 1; POLD1; Polymerase (DNA directed) delta 1 catalytic subunit 125kDa; Polymerase (DNA) delta 1 catalytic subunit; Polymerase DNA directed delta 1 catalytic subunit 125kD; polymerase, DNA, delta] |
| Gene, Accession # | [POLD1], Gene ID: 5424, NCBI: NP_001243778.1, UniProt: P28340 |
| Catalog # | MBS9605453 |
| Price | $240, $280 |
| Order / More Info | POLD1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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