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Antigenic Specificity | SETDB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-397 of human SETDB1 (NP 001230420.1). |
Other Names | [ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4] |
Gene, Accession # | [SETDB1], Gene ID: 9869, NCBI: Q15047.1, UniProt: Q15047 |
Catalog # | MBS8545929 |
Price | $280 |
Order / More Info | SETDB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |