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Antigenic Specificity | JAK2 |
Clone | [6B4-8G2-1C4] |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylat |
Immunogen | Immunogen: Synthetic peptide conjugated to KLH. |
Other Names | [Janus kinase 2; JTK10; Tyrosine protein kinase Jak2; THCYT3] |
Gene, Accession # | [JAK2], Gene ID: 3717, NCBI: NP_004963.1, UniProt: O60674 |
Catalog # | MBS8539830 |
Price | $280 |
Order / More Info | JAK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |