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Antigenic Specificity | Human CD40 |
Clone | [4A3A8] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | phycoerythrin (PE) conjugate |
Size | 50 tests, 100 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | 4A3A8 reacts with CD40 (Bp50), a member of the TNF receptor family with 48 kDa MW. which is expressed on B lymphocytes including pro-B through to plasma cells but not on monocytes nor granulocytes. CD40 also expressed on dendritic cells and CD34+ hemopoietic cell progenitor. CD40 molecule involved in regulation of B-cell growth, differentiation and Isotype-switching of Ig and up-regulates adhesion molecules on dendritic cells as well as promotes cytokine production in macrophages and dendritic cells. CD40 antibodies has been reported to co-stimulate B-cell proleferation with anti-m or phorbol esters. It may be an important target for control of graft rejection, T cells and antibody-mediated autoimmune diseases. |
Immunogen | n/a |
Other Names | [CD40, partial; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40 molecule; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: ABI49511.1 |
Catalog # | MBS8500381 |
Price | $280, $300 |
Order / More Info | Human CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Stamenkovic I et al., (1989) EMBO J. 8:1403. |