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Antigenic Specificity | ATG4D |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ATG4D antibody detects endogenous levels of total ATG4D. Function: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.Post-translational Modifications: Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately d |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Tissue Specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis. Predicted Cross Reactivity: Pig, Horse, Dog Similarity: Pig (80%), Horse (90%), Dog (90%) |
Other Names | [9830134P12Rik; APG4 autophagy 4 homolog D; APG4 D; APG4, S. cerevisiae, homolog of, D; APG4D; ATG4 autophagy related 4 homolog D (S. cerevisiae); Atg4d; ATG4D_HUMAN; Atg4dl; AUT like 4 cysteine endopeptidase; AUT-like 4 cysteine endopeptidase; AUTL4; Autophagin 4; Autophagin-4; autophagy 4, S. cerevisiae, homolog of, D; autophagy related 4D, cysteine peptidase; Autophagy related cysteine endopeptidase 4; Autophagy related protein 4 homolog D; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; Cysteine protease ATG4D; Cysteine protease involved in autophagy; MGC31226] |
Gene, Accession # | [ATG4D], Gene ID: 84971, NCBI: NP_001268433.1, UniProt: Q86TL0 |
Catalog # | MBS9605433 |
Price | $240, $280 |
Order / More Info | ATG4D Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |