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Antigenic Specificity | JPT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.7 mg/mL |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total JPT1 protein. Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408). |
Immunogen | Immunogen: Fusion protein of human JPT1 Immunogen Type: Peptide |
Other Names | [HN1; ARM2; HN1A] |
Gene, Accession # | [JPT1], Gene ID: 51155, NCBI: NP_001002032.1, UniProt: Q9UK76 |
Catalog # | MBS9430327 |
Price | $255 |
Order / More Info | JPT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |