Phospho-Stat3 (Tyr705) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Phospho-Stat3 (Tyr705) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Stat3 is constitutively activated in a number of human tumors (3, 4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6, 7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8, 9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3alpha (86 kDa) and Stat3beta (79 kDa) depend on cell type, ligand exposure, or cell maturat |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Tyr705 of human Stat3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [STAT3; APRF; HIES; FLJ20882; MGC16063] |
| Gene, Accession # | [Stat3], Gene ID: 6774, NCBI: NP_003141.2, UniProt: P40763 |
| Catalog # | MBS8527445 |
| Price | $310 |
| Order / More Info | Phospho-Stat3 (Tyr705) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Heim, M.H. (2001) J Recept Signal Transduct Res 19, 75-120. 2. Takeda, K. et al. (1997) Proc Natl Acad Sci U S A 94, 3801-4. 3. Catlett-Falcone, R. et al. (1999) Immunity 10, 105-15. 4. Garcia, R. and Jove, R. (1998) J Biomed Sci 5, 79-85. 5. Bromberg, J.F. et al. (1999) Cell 98, 295-303. 6. Darnell, J.E. et al. (1994) Science 264, 1415-21. 7. Ihle, J.N. (1995) Nature 377, 591-4. 8. Wen, Z. et al. (1995) Cell 82, 241-50. 9. Yokogami, K. et al. (2000) Curr Biol 10, 47-50. 10. Biethahn, S. et al. (1999) Exp Hematol 27, 885-94. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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