Edit |   |
---|---|
Antigenic Specificity | Caspase-3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse (expected from sequence) |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti caspase-3 antibody recognizes caspase-3 also known as cysteine protease CPP32. Caspase-3, as the name implies, is a member of the cysteine-aspartic acid protease (caspase) protein family.Caspase-3 is an effector caspase that is activated by both the intrinsic and extrinsic apoptosis pathways. Caspase-3 is cleaved from an inactive 32 kDa zymogen/pro-enzyme into p17 and p12 subunits by the activated initiator caspases 9 and 8 in apoptotic cells. These subunits dimerize to form the active caspase 3 protein that cleaves and activates caspase-6 and 2. Through the activation/cleavage of downstream caspases, caspase-3 plays an important role in mediating apoptosis signaling. |
Immunogen | Immunogen: Recombinant human caspase-3 |
Other Names | [Caspase-3], [CASP3; CASP3; CPP32; SCA-1; CPP32B; CPP32; CASP-3; CPP-32; SCA-1] |
Gene, Accession # | [CASP3], Gene ID: 836, NCBI: P42574.2, UniProt: P42574 |
Catalog # | MBS225328 |
Price | $375 |
Order / More Info | Caspase-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |