PRC1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PRC1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PRC1 antibody detects endogenous levels of total PRC1. Function: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).Subunit Structure: Homodimer (PubMed:20691902). Interacts with the C-terminal Rho-GAP domain and the basic region of RACG |
| Immunogen | Immunogen: A synthesized peptide derived from human PRC1 Subcellular Location: Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle Pole. Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Tissue Specificity: Overexpressed in bladder cancer cells (PubMed:17409436). |
| Other Names | [Anaphase spindle elongation 1 homolog; ASE1; PRC1; PRC1_HUMAN; Protein regulating cytokinesis 1; Protein regulator of cytokinesis 1] |
| Gene, Accession # | [PRC1], Gene ID: 9055, NCBI: NP_001254509.1, UniProt: O43663 |
| Catalog # | MBS9604424 |
| Price | $240, $280 |
| Order / More Info | PRC1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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