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Antigenic Specificity | RAB5A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed: 10818110, PubMed: 14617813, PubMed: 16410077, PubMed: 15378032). Contributes to the regulation of filopodia extension (PubMed: 14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed: 22660413). Regulates maturation of apoptotic cell-containing phagosome |
Immunogen | Immunogen: Recombinant Human Ras-related protein Rab-5A protein (1-215AA) |
Other Names | [Ras-related protein Rab-5A; RAB5A; RAB5] |
Gene, Accession # | [RAB5A], Gene ID: 5868, NCBI: NP_001278977.1, UniProt: P20339 |
Catalog # | MBS7048980 |
Price | $160, $235 |
Order / More Info | RAB5A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |