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Antigenic Specificity | Cathepsin B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Cathepsin B is a normal lysosomal cysteine proteinase that is expressed in all cells. It is synthesized as an inactive 43 kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of 31 kDa or the two-chain form (25 and 5 kDa subunits). Matured cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins. Elevated levels of cathepsin B correlate with malignancy smuggesting that this enzyme may be a useful prognostic marker for several types of human cancers. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 322 of human cathepsins B |
Other Names | [CTSB; CPSB; APPS; EC 3.4.22.1], [CTSB; CTSB; APPS; CPSB; CPSB; APPS] |
Gene, Accession # | Gene ID: 1508, NCBI: NP_001899.1, UniProt: P07858 |
Catalog # | MBS840873 |
Price | $150, $305 |
Order / More Info | Cathepsin B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |