Phospho-AKT1(Thr308) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-AKT1(Thr308) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-AKT1(Thr308) antibody detects endogenous levels of AKT1 only when phosphorylated at Threonine 308. Description: An AGC kinase that plays a critical role in controlling the balance between survival and AP0ptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. First found in a mouse transforming retrovirus. Tumorigenic in a mouse lymphoma model and activated (by phospho-Akt staining) and/or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription fac |
| Immunogen | Immunogen: A synthesized peptide derived from human AKT1 around the phosphorylation site of Threonine 308 Subcellular Location: Cytoplasm. Nucleus. Cell Membrane. Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form t |
| Other Names | [AKT 1; AKT; AKT1; AKT1_HUMAN; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha] |
| Gene, Accession # | [AKT1], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749 |
| Catalog # | MBS9600582 |
| Price | $240, $280 |
| Order / More Info | Phospho-AKT1(Thr308) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Yan H, Guo H, Cheng D, Kou R, Zhang C, Si J; Journal: Environ Toxicol. Tributyltin reduces the levels of serum adiponectin and activity of AKT and induces metabolic syndrome in male mice. Zhang W, Chen L, Ma K, Zhao Y, Liu X, Wang Y, Liu M, Liang S, Zhu H, Xu N; Journal: Oncotarget. Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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