Edit |   |
---|---|
Antigenic Specificity | ZAP70 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia. |
Immunogen | Immunogen: Purified recombinant fragment of human ZAP70 expressed in E. Coli. |
Other Names | [SRK; STD; TZK], [ZAP70; ZAP70; SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; SRK] |
Gene, Accession # | [ZAP70], Gene ID: 7535, NCBI: NP_001070.2, UniProt: P43403 |
Catalog # | MBS850844 |
Price | $280 |
Order / More Info | ZAP70 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |