p70 S6K Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | p70 S6K |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, bovine |
| Isotype | n/a |
| Format | APC-Cy7 conjugate |
| Size | 0.4 mL |
| Concentration | 0.25 mg/ml |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~70 kDa. Ribosomal S6 (S6K) belongs to the AGC family of Serine/Threonine protein kinases. There are two forms of S6K, alpha and beta, which have cytoplasmic and nuclear variants derived from alternative splicing (1). The activity of S6K is regulated by phosphorylation/dephosphorylation events in cellular responses to various extracellular stimuli. Its activity has also been shown to be dependent on nutrient availability (3-6). The mechanism of activation of S6K is a multi-step process which is achieved by phosphorylating the 40S ribosomal protein S6, which then upregulates the translation of mRNA transcripts containing an oligopryimidine tract at the 5' transcriptional start site (3-6). Recently, a highly homologous ribosomal S6 ki |
| Immunogen | Immunogen: Human p70 S6K c-terminal peptide-KLH conjugates |
| Other Names | [Rabbit Human p70 S6K; p70 S6 kinase beta (phospho T229); p70-beta; p70S6Kb; S6K beta; S6K2; SRK; STK14B; p70 S6K] |
| Gene, Accession # | [p70S6Kb], Gene ID: 6199, NCBI: NP_003943.2, UniProt: Q9UBS0 |
| Catalog # | MBS8004193 |
| Price | $395 |
| Order / More Info | p70 S6K Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Gout, I. et al. (1998). J Biol Chem. 273 (46):30061-30064. 2. Val'Ovka, TI. et al. (2000). Ukr Biokhim Zh. 72(3):31-7. 3. Kawasome, H. et al. (1998) Proc. Natl. Acad.Sci. 95. 4. Montagne, J. et al. 1999) Science 285. 5. Shima, H. et al. (1998) EMBO J 17: 6649-6659. 6. Lee-Fruman, K. et al. (1999) Oncogene 18: 5108-5114. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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