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Antigenic Specificity | RBM5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total RBM5 protein. Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.Bader S., Submitted (APR-1996) to the EMB |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human RBM5. |
Other Names | [G15; H37; LUCA15; RMB5; RNA binding motif protein 5] |
Gene, Accession # | [RBM5], Gene ID: 10181, NCBI: NP_005769.1, UniProt: P52756 |
Catalog # | MBS9408976 |
Price | $200, $255 |
Order / More Info | RBM5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |