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Antigenic Specificity | LIN28B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total LIN28B protein. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the b |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.242~246(P-S-V-Q-K) derived from Human LIN28B |
Other Names | [CSDD2; FLJ16517] |
Gene, Accession # | [LIN28B], Gene ID: 389421, NCBI: NP_001004317.1, UniProt: Q6ZN17 |
Catalog # | MBS9404957 |
Price | $200, $255 |
Order / More Info | LIN28B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |