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Antigenic Specificity | TEAD3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TEAD3 (NP 003205.2). |
Other Names | [TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3] |
Gene, Accession # | [TEAD3], Gene ID: 7005, NCBI: NP_003205.2, UniProt: Q99594 |
Catalog # | MBS8546824 |
Price | $280 |
Order / More Info | TEAD3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |